sickling of red blood cells can be produced in those with sickle cell anemia

Yes, exactly.
Sickle cell anemia occurs when a person inherits two abnormal genes (one from each parent) that cause their RBCs to change shape. Instead of being flexible & disc-shaped, these cells r more stiff & curved in the shape of the old farm tool known as a sickle — that is where the disease gets its name. The shape is similar to a crescent moon.
Sickle cell anemia occurs because an abnormal form of hemoglobin (HbS) is produced. HbS molecules tend to clump together, making red blood cells sticky, stiff, & more fragile, & causing them to form into a curved, sickle shape.